| Model | TUF GAMING B650-PLUS |
| CPU Support | AMD Socket AM5 for AMD Ryzen™ 7000 Series |
| Chipset | AMD B650 |
| Memory | 4 x DIMM, Max. 128GB, DDR5 6400+(OC) Dual Channel, OptiMem II |
| Graphics | 1 x DisplayPort, 1 x HDMI® port |
| Expansion Slots | 1 x PCIe 4.0/3.0 x16 slot(s), 2 x PCIe 4.0/3.0 x1 slots |
| Storage | 3 x M.2 slots, 4 x SATA 6Gb/s ports |
| Ethernet | 1 x Realtek 2.5Gb Ethernet, TUF LANGuard |
| USB | Rear: 8 ports, Front: 7 ports |
| Audio | Realtek 7.1 Surround Sound High Definition Audio CODEC |
| Back Panel I/O Ports | 1 x USB 3.2 Gen 2×2 port(s), 3 x USB 3.2 Gen 2 port(s), 4 x USB 2.0 port(s), 1 x DisplayPort, 1 x HDMI® port, 1 x Realtek 2.5Gb Ethernet port, 5 x Audio jacks |
| Special Features | ASUS TUF PROTECTION, ASUS Q-Design, ASUS Thermal Solution, ASUS EZ DIY, Aura Sync |
| Operating System | Windows® 11, Windows® 10 64-bit |
| Form Factor | ATX Form Factor |
