| Model | TUF GAMING B650M-PLUS |
| CPU | AMD Socket AM5 for AMD Ryzen™ 7000 Series |
| Chipset | AMD B650 |
| Memory | 4 x DIMM, Max. 128GB, DDR5 6400+(OC)/ 6200(OC)/ 6000(OC)/ 5800(OC)/ 5600(OC)/ 5400(OC)/ 5200/ 5000/ 4800 ECC & Non-ECC |
| Graphics | 1 x DisplayPort, 1 x HDMI® port |
| Expansion Slots | 1 x PCIe 4.0/3.0 x16 slot, 1 x PCIe 4.0/3.0 x16 slot (supports x4 mode), 1 x PCIe 4.0/3.0 x1 slot |
| Storage | Total supports 2 x M.2 slots and 4 x SATA 6Gb/s ports |
| Ethernet | 1 x Realtek 2.5Gb Ethernet |
| USB (Rear) | 1 x USB 3.2 Gen 2×2 port, 2 x USB 3.2 Gen 2 ports, 1 x USB 3.2 Gen 1 port, 4 x USB 2.0 ports |
| USB (Front) | 1 x USB 3.2 Gen 1 connector, 1 x USB 3.2 Gen 1 header, 2 x USB 2.0 headers |
| Audio | Realtek 7.1 Surround Sound High Definition Audio CODEC |
| Operating System | Windows®11, Windows®10 64-bit |
| Form Factor | micro-ATX Form Factor |
