| Model | TUF GAMING B660M-PLUS D4 |
| CPU | Intel® Socket LGA1700 for 13th & 12th Gen Intel® Core™, Pentium® Gold and Celeron® Processors |
| Memory | 4 x DIMM, Max. 128GB, DDR4, Dual Channel, Supports Intel® Extreme Memory Profile (XMP), OptiMem II |
| Graphics | 1 x DisplayPort, 1 x HDMI® port |
| Expansion Slots | 1 x PCIe 5.0 x16 slot, 1 x PCIe 3.0 x16 slot, 1 x PCIe 4.0 x1 slot |
| Storage | 2 x M.2 slots, 4 x SATA 6Gb/s ports |
| Ethernet | 1 x Realtek 2.5Gb Ethernet, TUF LANGuard |
| USB | Rear: 8 ports, Front: 7 ports |
| Audio | Realtek 7.1 Surround Sound High Definition Audio CODEC |
| Back Panel I/O Ports | 1 x USB Type-C®, 4 x USB 3.2 Gen 2 ports, 1 x DisplayPort, 1 x HDMI® port, etc. |
| Internal I/O Connectors | Fan and Cooling related, Power related, Storage related, USB, Miscellaneous |
| Special Features | ASUS TUF PROTECTION, ASUS Q-Design, ASUS Thermal Solution, ASUS EZ DIY, AURA Sync |
| Operating System | Windows® 11, Windows® 10 64-bit |
| Form Factor | microATX, 24.4cm x 24.4cm |
